AYURVEDIC MANAGEMENT FOR SYSTEMIC PAIN & INFLAMMATION - HERBAL DESTINATION TO REVIVE BONES STRENGTH

Ayurvedic Management of Systemic Pain & Inflammation- Revive Bones Strength by Herbal Destination

Inflamation and Pain have been there since the history of Ayurveda. It is refered to as “SOTHA”. It is phenomenon which is principally caused by an injury. The body causes inflammation as a defense mechanism of the immune system. It can be controlled by several mechanisms pertaining prostaglandins (COX, LOX), inflammatory cytokines (TNF-alpha), nociception receptors (vaniloid receptors), TRP receptors, sodium potassium channel, cannabinoid receptors (CB1, CB2)

Historically various single molecules have been used as anti-inflammatory and pain management effort. We believe in systems pharmacology which deals with various receptor mechanisms as well as controlling the threshold of pain. The different herbs used are assorted gift of nature to insult the jostle of pain in a concerted manner taking a systems approach.

 

Our traditional herbs are for managing pain & swelling in arthritis. This ideal poly-herbal formulation helps in managing arthritis as an anti-inflammatory agent and pain reliever. The predominant effect of the combination prevents further deterioration in joints & rejuvenates the damaged cartilage & makes the drug as an ideal choice in the management of Osteo & Gout arthritis.

A NEXT GENERATION DRUG DESIGN

SALLAKI (Boswellia Serrata)

β-boswellic acid, which inhibits microsomal prostaglandin E synthase-1 and the serine protease cathepsin G are the molecular targets related to the anti-inflammatory properties of Boswellia serrata extract (BSE).

Clinical trials and the experimental data from in vitro studies of BSE suggest its safety and efficacy.

Available pharmacokinetic and metabolic data on boswellic acids suggests it as a next generation NSAID with which is safe and bioavailable hence effective.

Ref- Tawab et al.Clinical Pharmacokinetics 2011,50:6, pp 349-369.

A NOVEL MECHANISM OF ACTION

PIPPALI (Piper Longum) – Root

Piperine is known to decrease inflammation by decreasing the cytokine expression.

It decreses pro-inflammatory cytokines expression in the subcutaneous adipose tissue, an effect independent of adiposity, immune cells recruitment, angiogenesis or modulation of gut bacteria controlling inflammation.

Ref- Neyrink et al.PLoS One2013 Nov 19;8(11).

 

IMPROVED AYURVEDA PHARMACOLOGY

SHIGRU (Moringa Olifera) – Stem Bark

Moringa oleifera Extract (MOE) significantly facilitates synaptogenesis. The β-carotene, one major compound of MOE, promoted neuritogensis, but the increase was not comparable with the effect of MOE.

50 µg/mL exhibited anti-inflammatory activity on lipo-polyssaccharide-stimulated murine macrophages by regulating the production of nitric oxide, with similarly reduced Levels TNF-α and IL-1β.

Ref- Hannan et al. J. Ethnopharmacology 2013 Dec 31. doi: 10.1016/j.jep.2013.12.036.

PROGRESSIVE ARTHRITIS CONTROL

Anantmool (Hemidesmus Indicus) – Root

Terpenoids from Hemidesmus indicus show ameliorative control in arthritis.

 

Rasna (Pluchea Lanceolata) – Leaf & Root

Taraxasterol (Tx) from Pluchea lanceolata attenuates the release of pro-inflammatory cytokines, such as TNF-α, IFN-γ, and IL-6

Ref: Mehta et al. Asian Pac J Trop Med. 2012 Feb;5(2):130-5.

Srivastava al.Naunyn Schmidebergs Arch Pharmacol. 2013 Oct 8. [Epub ahead of print]

                                                                                                                            

IMPROVED PATIENT COMPLAINCE

GURUCHI (Tinospora Cordifolia) – Stem

Tinospora cordifolia is described as Rasayana in Ayurveda and hence shows immunomodulatory effect. Overall rejuvenation of geriatric patients

Improved body immunity & enhanced patient compliance. Also effective to combat cross target toxicity and side effects.

GUGGUL (Commiphora Mukul) – Resin

Attenuates pheripheral neuropathic pain induced by chronic constriction injury at sciatic nerve. (Reff: Nutr neurosci.2014 jan16.E pub)

E-Guggulosterone contain hypocholesterolemic effect. (Reff: Indian J Med Res.2013 Feb;137(2):14p)

Guggulosterone reverses drug resistance in imatinib-resistant leukamic cells by inhibiting cyclo-oxygenase-2 and p-glycoprotein.

Ref: phytomedicine.2014 jun 15;21(7):10049.doi;10.1016/j.phymed.2014.02.014.Epub2014 Mar 26.)

 

RAKTA PUNARNAVA (Boerhavia Diaffusa) – Whole Plant

This plant is also called sothaghni which means that who alleviate inflammation. Liriodendrin (eleutheroside E; syringaresinol diglucoside), quercetin, and kaempferol are present in various extracts from roots and leaves of the plant and have potential for anti-inflammatory activity.

 

SWET ERANDA (Riccinus Communis) – Root

Methanolic extract of Ricinus communis root possess significant anti-inflammatory activity in acute and chronic inflammation. Two triterpenes, one compound lupeol and a new diketone pentacyclic triterpene named as erandone (urs-6-ene-3,16-dione) extracted by various spectroscopic techniques exhibited anti-inflammatory activity. Ricinoleic acid has the potential to be a new capsaicin-like substance representing a class of potent anti-inflammatory compound.

 

SHUNTHI (Zingiber Officinalis) – Rhizome

Gingerol & gingerone has antioxidant, anti inflammatory, analgesic & anti-tumor action which reduce pain and swelling.

POLY HERBAL formulation may change the concept of pain management & inflammation.

 

INDICATION: Useful against osteo & gout arthritis, osteoporosis, injury, joint and muscle pain, musculoskeletal disorder, low back pain, spinal disorders etc.